Best-rated hotels in Picayune for your unforgettable stay

Detailed descriptions, travelers’ reviews, and handpicked hotel collections will help you book your perfect accommodation.

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Choose from exclusive hotel collection

We offer thousands of Picayune hotels and accommodations from world's renowned hotel chains to unique gems of the region you won’t find anywhere else.

Enjoy seamless booking experience

Once you choose your best place to stay, take a minute to complete a quick reservation form and get an instant confirmation letter to your email address.

Benefit from flexible travel options

We provide the most flexible cancellation options, so you get your deposit back in case of a change of plans or other unforeseen circumstances.

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Hotels by class
3 stars 1
2 stars 3
Unrated 8
Accommodation type
Holiday homes 5
Motels 2
Hotels 2
Villa 1
Guest house 1
Lodge 1
Thematic Hotels
Pet-friendly hotels 10
Vacation Rentals 7
Extended Stay 7
Family Friendly hotels 5
Luxury accommodations 4
Private Villas 3
Golf hotels 2
Cheap and budget hotels 2
Spa hotels 1
Hotels with indoor pool 1
Business hotels 1
All Picayune hotels

Hotels by location

Nearby
City Center Picayune 5
Saint Charles Parish Hall Picayune 5
NASA Stennis Space Center Picayune 5
Picayune Recreation Dept 5
Picayune Shopping Center 5
Fun Center Picayune 5
Landmarks
Parks
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Popular attractions
Mississippi >
Picayune

Welcome to Picayune

Discover the charm of Picayune, a hidden gem in southern Mississippi. Immerse yourself in the rich history and vibrant culture as you explore quaint streets lined with local shops and eateries. Unwind in the natural beauty of nearby parks and lakes. Visit Picayune and experience the perfect blend of small-town charm and southern hospitality.

What our users say about Picayune hotels

Hard Rock Hotel & Casino Biloxi
9.8

Exceptional

us John 24 December 2022
This place was cool, with its cozy rooms and an awesome location. The staff were really nice and welcoming. 👍
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Margaritaville Resort Biloxi
9.8

Exceptional

us Ray 24 December 2022
The location was great, just a 5-minute walk to the casinos. It was in a lovely area near the Margaritaville restaurant. This made it a convenient base for my stay.
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Golden Nugget Biloxi
9.8

Exceptional

us William 24 October 2022
The hotel was fairly clean. Facilities were clean. - Marvellous location just off the casino. - the food was appetising with plenty of alternatives. - Nothing too much trouble. - Appreciated my stay at this venue.
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South Beach Biloxi Hotel & Suites
9.8

Exceptional

us Karl 29 December 2022
The whole experience was amazing! Loved my 2 nights stay. - Booked a room with awesome views of the beach. - Every staff member was wonderful and pleasant. - My check in was good.
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Beau Rivage Resort & Casino
9.8

Exceptional

us Paul 24 January 2023
The location of the hotel was great, as it was close to the casino in Biloxi. Additionally, the hotel was conveniently situated near the Hurricane Katrina Memorial. The room had fantastic views and provided a pleasant atmosphere for my three-night stay. The breakfast offered was consistently delicious and of high quality.
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Scarlet Pearl Casino Resort
9.8

Exceptional

us Clifford 15 September 2022
the hotel is clean with courteous staff. the breakfast was amazing and had a 4-star level. 3. the room was gorgeous, relaxing, and had a great view. 4. the room came with extra towels and shower caps.
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Harrah'S Gulf Coast, A Caesars Destination
9.8

Exceptional

us Marcus 19 July 2022
The hotel was upscale with delicious and affordable breakfasts. I got a well-maintained room with a private bathroom. the venue had a gorgeous location near St Michael's Catholic Church. I loved the indoor restaurants around.
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Ip Casino Resort & Spa
9.8

Exceptional

us Donna 26 April 2023
Trendy building, rooms nicely done with a lovely view 😊.
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Magnolia Bluffs, BW Signature Collection
9.8

Exceptional

us Alexander 27 January 2023
This place was fantastic, situated right by the river, in a peaceful location close to Natchez Gazebo and near the city center and a casino.
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Hotel Legends
9.8

Exceptional

us John 16 March 2022
This place was comfortable for exploring the area, and we liked it because we got a room with a bath.
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Save time on your trip arrangements by booking one of our hand-picked hotels

Exclusive 3-star hotels
Quality 2-star hotels
Enjoy truly authentic experiences without compromising comfort and convenience.
Super 8 By Wyndham Picayune

999 Cooper Rd, Picayune, United States

Average
86 reviews

67 US$

min. price/night

Discover the hidden gems of Picayune by booking one of its budget-friendly hotels.
Holiday Inn Express Hotel & Suites Picayune By Ihg

1001 Dauphin Street, Picayune, United States

Good
113 reviews

88 US$

min. price/night

Days Inn By Wyndham Picayune

450 S Lofton Ave,, Picayune, United States

Average
69 reviews

69 US$

min. price/night

Heritage Inn

1122 Memorial Boulevard, Picayune, United States

150 US$

min. price/night

Travelers’ choice

Check out the most booked accommodations to find reliable places that our users have tried and tested.
Pet-Friendly Picayune Tiny Home Near Space Center!

11 Main House Dr Unit B, Picayune, United States

Excellent
3 reviews

Picayune Tiny Home Rental About 11 Mi To Space Center!

18 Main House Dr, Picayune, United States

Excellent
2 reviews

Cozy Picayune Tiny Home Rental About 4 Mi To Downtown!

11 Main House Dr Unit D, Picayune, United States

Excellent
2 reviews

Econo Lodge

550 South Lofton Dr., Picayune, United States

74 US$

min. price/night

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